SUBSTITUTION AS A MECHANISM FOR GENETIC ROBUSTNESS: THE DUPLICATED DEACETYLASES HST1P AND SIR2P IN SACCHAROMYCES CEREVISIAE.

Substitution as a mechanism for genetic robustness: the duplicated deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae.

How duplicate genes provide genetic robustness remains an unresolved question.We have examined the duplicated histone deacetylases Sir2p and Hst1p in Saccharomyces cerevisiae and find that these paralogs with non-overlapping functions can provide genetic robustness against null mutations through a substitution mechanism.Hst1p is an NAD(+)-dependent

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Prevalence of pressure ulcers and associated factors among adult patients admitted at Comprehensive Specialized Hospital, Northwest Ethiopia, 2023

harmoni headband Abstract Pressure ulcers are a serious concern in patients with prolonged bedtime and present with common complications following surgery.It is one of the key performance indicators of the quality of nursing care provided to patients.Several studies have reported the prevalence of pressure ulcers in Ethiopia, but the current study

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